2-[(tert-butoxycarbonyl)amino]-5-methoxybenzoic acid

2-[(tert-butoxycarbonyl)amino]-5-methoxybenzoic acid - Names and Identifiers

Name	2-[(tert-butoxycarbonyl)amino]-5-methoxybenzoic acid
Synonyms	2-[(tert-Butoxycarbonyl)amino]-5-methoxybenzoic acid 2-[(tert-butoxycarbonyl)amino]-5-methoxybenzoic acid Benzoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-methoxy- 5-Methoxy-2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid Benzoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-methoxy- (9CI)
CAS	262614-64-2
InChI	InChI=1/C13H17NO5/c1-13(2,3)19-12(17)14-10-6-5-8(18-4)7-9(10)11(15)16/h5-7H,1-4H3,(H,14,17)(H,15,16)

2-[(tert-butoxycarbonyl)amino]-5-methoxybenzoic acid - Physico-chemical Properties

Molecular Formula	C13H17NO5
Molar Mass	267.28
Density	1.243±0.06 g/cm3(Predicted)
Boling Point	366.7±32.0 °C(Predicted)
Flash Point	175.6°C
Vapor Presure	5.04E-06mmHg at 25°C
pKa	3.58±0.36(Predicted)
Refractive Index	1.562

2-[(tert-butoxycarbonyl)amino]-5-methoxybenzoic acid - Introduction

2-[(tert-butoxycarbonyl)amino]-5-methoxybenzoic acid is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: White crystalline solid
-Molecular formula: C16H21NO5
-Molecular weight: 315.34g/mol
-Melting Point: 160-165 ° C
-Solubility: Slightly soluble in water, soluble in organic solvents such as dimethylformamide (DMF), dichloromethane (DCM), etc.

Use:
- 2-[(tert-butoxycarbonyl)amino]-5-methoxy benzoic acid is a commonly used organic synthesis intermediate. It is widely used in drug synthesis, Pesticide Synthesis and the synthesis of other organic molecules.
-It can be used to synthesize a variety of biologically active compounds, such as drugs, pesticides and functional materials.

Method:
The preparation method of 2-[(tert-butoxycarbonyl)amino]-5-methoxy benzoic acid is as follows:
1. First, 2-amino -5-methoxy benzoic acid and dimethylformamide (DMF) are dissolved in dichloromethane, and tetrabutyl Potassium hydride (TBAB) is added as a catalyst.
2. Then the Boc-2-amino acetate in the lid filter device is slowly added dropwise to the reaction solution.
3. After completion of the reaction, the reaction solution was acidified with an acid.
4. Finally, the target product is obtained by vacuum filtration or crystallization.

Safety Information:
- 2-[(tert-butoxycarbonyl)amino]-5-methoxy benzoic acid is generally relatively safe under normal operating conditions, but the following matters still need to be noted:
-Inhalation, ingestion, contact with skin or eyes may cause health hazards, so use should be careful to avoid direct contact.
-Wear appropriate chemical laboratory protective equipment, such as gloves, goggles and lab clothes, during operation.
-When used indoors, good ventilation should be provided.
-If taken by mistake or contact by mistake, rinse immediately with plenty of water and seek medical advice.

Please note that when using and handling chemical reagents, always follow the correct laboratory safety operating procedures, and operate according to specific experimental conditions and requirements.

Last Update：2024-04-09 21:00:56